GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UVM | cis | rs10935120 | 1 | rs2056604 | chr3:134312648 | ANAPC13 | chr3:134196547-134204865:- | 0.45 | 6.73 | 1.03E-8 | Height |
| UVM | cis | rs703842 | 1 | rs2069502 | chr12:58144665 | TSFM | chr12:58176536-58191367:+ | 0.57 | 5.04 | 5.32E-6 | Multiple sclerosis |
| UVM | cis | rs2071358 | 1 | rs2071358 | chr12:48366449 | HDAC7 | chr12:48176509-48213763:- | -0.66 | -4.73 | 1.63E-5 | Gestational age at birth (child effect) |
| UVM | cis | rs2071518 | 1 | rs2071518 | chr8:120435812 | NOV | chr8:120428552-120436678:+ | 0.6 | 4.95 | 7.51E-6 | Blood pressure |
| UVM | cis | rs703842 | 1 | rs2072052 | chr12:58146719 | TSFM | chr12:58176536-58191367:+ | -0.57 | -5.04 | 5.32E-6 | Multiple sclerosis |
| UVM | cis | rs2239557 | 1 | rs2072293 | chr14:74537885 | LIN52 | chr14:74551656-74667117:+ | 0.44 | 5.65 | 5.92E-7 | Common traits (Other) |
| UVM | cis | rs2074038 | 1 | rs2074038 | chr11:44087989 | ACCS | chr11:44087475-44105569:+ | 0.91 | 5.83 | 3.07E-7 | IgA nephropathy |
| UVM | cis | rs4660306 | 1 | rs2077808 | chr1:45988115 | CCDC163P | chr1:45960581-45965646:- | -0.76 | -7.95 | 1.07E-10 | Homocysteine levels |
| UVM | cis | rs10461617 | 1 | rs2113078 | chr5:56087190 | C5orf35 | chr5:56205103-56213010:+ | 1.05 | 6.59 | 1.79E-8 | Type 2 diabetes |
| UVM | cis | rs10461617 | 1 | rs2113079 | chr5:56157951 | C5orf35 | chr5:56205103-56213010:+ | 0.95 | 6.93 | 4.86E-9 | Type 2 diabetes |
| UVM | cis | rs3919627 | 1 | rs2114883 | chr3:42882668 | VIPR1 | chr3:42544104-42579065:+ | -0.63 | -4.73 | 1.63E-5 | Obesity-related traits |
| UVM | cis | rs2985684 | 1 | rs2147712 | chr14:50091684 | RPL36AL | chr14:50085407-50087349:- | 0.54 | 5.79 | 3.51E-7 | Carotid intima media thickness |
| UVM | cis | rs1003719 | 1 | rs2154536 | chr21:38492147 | PIGP | chr21:38437664-38445458:- | -0.63 | -4.93 | 8.02E-6 | Eye color traits |
| UVM | cis | rs2564921 | 1 | rs2163167 | chr3:53131772 | RFT1 | chr3:53122503-53164470:- | -0.37 | -5.27 | 2.35E-6 | Height |
| UVM | cis | rs10935120 | 1 | rs2177601 | chr3:134245434 | ANAPC13 | chr3:134196547-134204865:- | -0.46 | -6.87 | 6.1E-9 | Height |